Neck Solutions

Subendplate microcirculation disturbance directly contributes to intervertebral disc degeneration

From: Zhonghua Wai Ke Za Zhi. 2008 Feb 1;46(3):213-6 Article in Chinese

To build subendplate microcirculation disturbance animal model and to investigate the potential pathogenesis of intervertebral disc degeneration. Twenty four New Zealand white rabbits were divided into treatment group (Group A) and control group (Group B). In Group A, animals received endotoxin and corticosteroid application to build subendplate microcirculation disturbance animal model, validated by microthrombus staining. In Group B, animals were given no drug, but standard feeding. After 3 month, the extent of intervertebral disc degeneration was evaluated by the water content, biochemistry analysis, and morphology. Subendplate microthrombus staining confirmed the exist of microcirculation disturbance.

The water content and biochemistry components content of disc in Group A were lower than those of disc in Group B, and intervertebral disc degeneration was observed in morphology. Subendplate microcirculation disturbance can directly contribute to intervertebral disc degeneration, the nutrients diffusion barrier is the potential pathogenesis of intervertebral disc degeneration.